Shoko Sashiyama, Tadashi Nakagawa, Makiko Nakagawa, Masaki Hosogane, Yasuaki Watanabe, Honoka Ashitomi, Kazusa Yamane, Norihiro Shibuya, Toshiro Moroishi, Keiko Nakayama, Toru Hosoi

KBG syndrome-associated protein ANKRD11 regulates SETD5 expression to modulate rRNA levels and translation

iScience. 2025 May 19;28(6):112699.  doi: 10.1016/j.isci.2025.112699.  eCollection 2025 Jun 20.

Takashi Matsumoto, Akihiro Nita, Yohei Kanamori, Ayato Maeda, Tomomi Nita, Noriko Yasuda-Yoshihara, Kosuke Mima, Hirohisa Okabe, Katsunori Imai, Hiromitsu Hayashi, Yuta Matsuoka, Katsuya Nagaoka, Keiichi I Nakayama, Yuki Sugiura, Yasuhito Tanaka, Hideo Baba, Toshiro Moroishi

Integrated hepatic ferroptosis gene signature dictates pathogenic features of ferroptosis

Hepatol Commun. 2025 May 29;9(6):e0721.  doi: 10.1097/HC9.0000000000000721. eCollection 2025 Jun 1.

Soh Ishiguro, Kana Ishida, Rina C Sakata, Minori Ichiraku, Ren Takimoto, Rina Yogo, Yusuke Kijima, Hideto Mori, Mamoru Tanaka, Samuel King, Shoko Tarumoto, Taro Tsujimura, Omar Bashth, Nanami Masuyama, Arman Adel, Hiromi Toyoshima, Motoaki Seki, Ju Hee Oh, Anne-Sophie Archambault, Keiji Nishida, Akihiko Kondo, Satoru Kuhara, Hiroyuki Aburatani, Ramon I Klein Geltink, Takuya Yamamoto, Nika Shakiba, Yasuhiro Takashima, Nozomu Yachie

A multi-kingdom genetic barcoding system for precise clone isolation

Nat Biotechnol. 2025 May 21.  doi: 10.1038/s41587-025-02649-1.  Online ahead of print.

Hao Li, Shuran Li, Yohei Kanamori, Saisai Liu, Toshiro Moroishi

Anticancer and cancer preventive activities of shogaol and curcumin from Zingiberaceae family plants in KG-1a leukemic stem cells

Biochem Biophys Res Commun. 2025 May 11:770:151992.  doi: 10.1016/j.bbrc.2025.151992.

Yumi Aoyama, Hiromi Yamazaki, Koutarou Nishimura, Masaki Nomura, Tsukasa Shigehiro, Takafumi Suzuki, Weijia Zang, Yota Tatara, Hiromi Ito, Yasutaka Hayashi, Yui Koike, Miki Fukumoto, Atsushi Tanaka, Yifan Zhang, Wataru Saika, Chihiro Hasegawa, Shuya Kasai, Yingyi Kong, Yohei Minakuchi, Ken Itoh, Masayuki Yamamoto, Shinya Toyokuni, Atsushi Toyoda, Tomokatsu Ikawa, Akifumi Takaori-Kondo, Daichi Inoue

Selenoprotein-mediated redox regulation shapes the cell fate of HSCs and mature lineages

Blood. 2025 Mar 13;145(11):1149-1163.  doi: 10.1182/blood.2024025402.

Pawaret Panyajai, Natsima Viriyaadhammaa, Sawitree Chiampanichayakul, Yasuhisa Sakamoto, Siriporn Okonogi, Toshiro Moroishi, Songyot Anuchapreeda

Anticancer and cancer preventive activities of shogaol and curcumin from Zingiberaceae family plants in KG-1a leukemic stem cells

BMC Complement Med Ther. 2025 Feb 28;25(1):87.  doi: 10.1186/s12906-025-04829-7.

Tatsuya Morishima, Md Fakruddin, Yohei Kanamori, Takeshi Masuda, Akiko Ogawa, Yuxin Wang, Vivien A C Schoonenberg, Falk Butter, Yuichiro Arima, Takaaki Akaike, Toshiro Moroishi, Kazuhito Tomizawa, Toshio Suda, Fan-Yan Wei, Hitoshi Takizawa

Mitochondrial translation regulates terminal erythroid differentiation by maintaining iron homeostasis

Sci Adv. 2025 Feb 21;11(8):eadu3011.  doi: 10.1126/sciadv.adu3011.  Epub 2025 Feb 21.

Yuichiro Iwamoto, Benjamin Salmon, Yusuke Yoshioka, Ryosuke Kojima, Alexander Krull, Sadao Ota

High throughput analysis of rare nanoparticles with deep-enhanced sensitivity via unsupervised denoising

Nat Commun. 2025 Feb 20;16(1):1728.  doi: 10.1038/s41467-025-56812-y.

Yifan Zhang, Masaki Nomura, Koutarou Nishimura, Weijia Zang, Yui Koike, Muran Xiao, Hiromi Ito, Miki Fukumoto, Atsushi Tanaka, Yumi Aoyama, Wataru Saika, Chihiro Hasegawa, Hiromi Yamazaki, Akifumi Takaori-Kondo, Daichi Inoue

In-depth functional analysis of BRD9 in fetal hematopoiesis reveals context-dependent roles

iScience. 2025 Feb 12;28(3):112010.  doi: 10.1016/j.isci.2025.112010.  eCollection 2025 Mar 21.

Takafumi Kasai, Kyohhei Fujita, Toru Komatsu, Tasuku Ueno, Ryosuke Kojima, Kenjiro Hanaoka, Yasuteru Urano

Development of a near-infrared fluorescent probe for the selective detection of severe hypoxia

RSC Chem Biol. 2025 Feb 4;6(3):449-456.  doi: 10.1039/d4cb00243a.  eCollection 2025 Mar 5.

Yasuhisa Sakamoto, Akiyoshi Uezu, Koji Kikuchi, Jangmi Kang, Eiko Fujii, Toshiro Moroishi, Shiro Suetsugu, Hiroyuki Nakanishi

The Nedd4L ubiquitin ligase is activated by FCHO2-generated membrane curvature

EMBO J. 2024 Dec;43(23):5883-5909.  doi: 10.1038/s44318-024-00268-1.  Epub 2024 Oct 14.

Tomoya Yamashita, Haruki Horiguchi, Tsuyoshi Kadomatsu, Michio Sato, Toshiro Moroishi, Yuichi Oike

Immunotherapy-induced reprogramming of cancer-associated fibroblasts can promote tumor progression

Genes Cells. 2024 Dec;29(12):1275-1283.  doi: 10.1111/gtc.13177.  Epub 2024 Oct 30.

Shinsei Yumoto, Haruki Horiguchi, Tsuyoshi Kadomatsu, Taichi Horino, Michio Sato, Kazutoyo Terada, Keishi Miyata, Toshiro Moroishi, Hideo Baba, Yuichi Oike

Host ANGPTL2 establishes an immunosuppressive tumor microenvironment and resistance to immune checkpoint therapy

Cancer Sci. 2024 Dec;115(12):3846-3858.  doi: 10.1111/cas.16348.  Epub 2024 Sep 25.

Koki Kunitake, Tadahaya Mizuno, Kazuki Hattori, Chitose Oneyama, Mako Kamiya, Sadao Ota, Yasuteru Urano, Ryosuke Kojima

Barcoding of small extracellular vesicles with CRISPR-gRNA enables comprehensive, subpopulation-specific analysis of their biogenesis and release regulators

Nat Commun. 2024 Nov 19;15(1):9777.  doi: 10.1038/s41467-024-53736-x.

Hao Li, Yohei Kanamori, Toshiro Moroishi

Cell attachment defines sensitivity to cold stress via the Hippo pathway

Biochem Biophys Res Commun. 2024 Oct 20:730:150373.  doi: 10.1016/j.bbrc.2024.150373. Epub 2024 Jul 9.

Chanida Thinyakul, Yasuhisa Sakamoto, Mayuko Shimoda, Yanliang Liu, Suyanee Thongchot, Omnia Reda, Akihiro Nita, Romgase Sakamula, Somponnat Sampattavanich, Ayato Maeda, Paweenapon Chunthaboon, David Nduru, Mayumi Niimura, Yohei Kanamori, Peti Thuwajit, Keiichi I Nakayama, Kun-Liang Guan, Yorifumi Satou, Chanitra Thuwajit, Toshiro Moroishi

Hippo pathway in cancer cells induces NCAM1+αSMA+ fibroblasts to modulate tumor microenvironment

Commun Biol. 2024 Oct 17;7(1):1343.  doi: 10.1038/s42003-024-07041-4.

Toshihiro Nakane, Ryoya Nakagawa, Soh Ishiguro, Sae Okazaki, Hideto Mori, Yutaro Shuto, Keitaro Yamashita, Nozomu Yachie, Hiroshi Nishimasu, Osamu Nureki

Structure and engineering of Brevibacillus laterosporus Cas9

Commun Biol. 2024 Jul 3;7(1):803.  doi: 10.1038/s42003-024-06422-z.

Hiroyoshi Fujioka, Yuta Murao, Momoko Okinaka, Spencer John Spratt, Jingwen Shou, Minoru Kawatani, Ryosuke Kojima, Ryo Tachibana, Yasuteru Urano, Yasuyuki Ozeki, Mako Kamiya

Cyano-Hydrol green derivatives: Expanding the 9-cyanopyronin-based resonance Raman vibrational palette

Bioorg Med Chem Lett. 2024 Jul 1:106:129757.  doi: 10.1016/j.bmcl.2024.129757. Epub 2024 Apr 16.

Koki Murata, Kai Harayama, Mayuko Shimoda, Mayumi Niimura, Masahiro Wakao, Yasuo Suda, Toshiro Moroishi, Hiroyuki Shinchi 

Improvement of the Nuclease Resistance and Immunostimulatory Activity of CpG Oligodeoxynucleotides by Conjugation to Sugar-Immobilized Gold Nanoparticles

Bioconjug Chem. 2024 Jun 19;35(6):804-815.  doi: 10.1021/acs.bioconjchem.4c00145. Epub 2024 May 8.

Yukiteru Nakayama, Katsuhito Fujiu, Tsukasa Oshima, Jun Matsuda, Junichi Sugita, Takumi James Matsubara, Yuxiang Liu, Kohsaku Goto, Kunihiro Kani, Ryoko Uchida, Norifumi Takeda, Hiroyuki Morita, Yingda Xiao, Michiko Hayashi, Yujin Maru, Eriko Hasumi, Toshiya Kojima, Soh Ishiguro, Yusuke Kijima, Nozomu Yachie, Satoshi Yamazaki, Ryo Yamamoto, Fujimi Kudo, Mio Nakanishi, Atsushi Iwama, Ryoji Fujiki, Atsushi Kaneda, Osamu Ohara, Ryozo Nagai, Ichiro Manabe, Issei Komuro

Heart failure promotes multimorbidity through innate immune memory

Sci Immunol. 2024 May 24;9(95):eade3814.  doi: 10.1126/sciimmunol.ade3814. Epub 2024 May 24.

Akihiro Nita, Toshiro Moroishi

Hippo pathway in cell–cell communication: emerging roles in development and regeneration

Inflamm Regen. 2024 Apr 2;44(1):18.  doi: 10.1186/s41232-024-00331-8.

Asako Tsubouchi, Yuri An, Yoko Kawamura, Yuichi Yanagihashi, Hirofumi Nakayama, Yuri Murata, Kazuki Teranishi, Soh Ishiguro, Hiroyuki Aburatani, Nozomu Yachie, Sadao Ota

Pooled CRISPR screening of high-content cellular phenotypes using ghost cytometry

Cell Rep Methods. 2024 Mar 25;4(3):100737.  doi: 10.1016/j.crmeth.2024.100737.